Anti-CCP refers to the anti-cyclic citrullinated peptide. It is kind of an antibody that is produced by the immune system. These consider the patient’s cells as the foreign cells and start attacking them. Such kind of attacks can give birth to inflammatory symptoms which are most commonly seen in rheumatoid arthritis. Research shows 7 out of 10 Rheumatoid Arthritis (RA) patients have anti-CCP.

Another name for anti-CCP: Anticitrullinated protein antibodies or ACPAs.

How does the anti-CCP test conduct?

ANTI-CCP is a blood test. The blood sample is drawn from the vein and then sent for the test in a lab. If the blood holds the anti-CCP in itself then the result comes as positive. Low level of anti-CCP may be found in the test but if the antibodies are not enough to call the RA positive and still the symptoms of Rheumatoid Arthritis can be seen then retesting might be required.

Causes of anti-CCP:

It is believed that anti-CCP can be produced because of genetics and environmental factors. Researchers have found that patients of Rheumatoid Arthritis have common series of amino acids and known as shared epitope that is encoded in special genetic markers known as Human Leukocyte Antigens or HLA.

The HLA is responsible for making proteins which control immune signals. Some researchers’ report clearly mentions that the shared epitope meets with the proteins and give birth to the ani-CCP antibodies in a body.

While some researches reports reveal that patients who have shared epitope, there are more chances of rheumatoid arthritis to them if they smoke.

Some researchers predicted that the smoking cause lung inflammation which can produce anti-CCP antibodies in patients body who have the shared epitope.